Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant
نویسندگان
چکیده
منابع مشابه
Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.
Lumbar disc degeneration (LDD) is associated with both genetic and environmental factors and affects many people worldwide. A hallmark of LDD is loss of proteoglycan and water content in the nucleus pulposus of intervertebral discs. While some genetic determinants have been reported, the etiology of LDD is largely unknown. Here we report the findings from linkage and association studies on a to...
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چکیده ندارد.
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STUDY DESIGN Prospective study of 212 patients with groin pain but without low back pain. OBJECTIVE To evaluate discogenic groin pain without low back pain or radicular pain. SUMMARY OF BACKGROUND DATA Patients feel low back pain originating from discogenic disease. It has been reported that the rat lower lumbar discs are innervated mainly by L2 dorsal root ganglion neurons. Thus, it is pos...
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STUDY DESIGN A literature review. OBJECTIVE To synthesize the scientific literature on the prevalence of lumbar disc degeneration and factors associated with its occurrence, including genetic influences. METHODS A literature review was conducted of the prevalence of disc degeneration. Studies of the etiology of disc degeneration were summarized, with particular attention given to studies of...
متن کاملThe lumbar intervertebral disc: from embryonic development to degeneration.
Lumbar intervertebral discs (IVDs) are prone to degeneration upon skeletal maturity. In fact, this process could explain approximately 40% of the cases of low back pain in humans. Despite the efficiency of pain-relieving treatments, the scientific community seeks to develop innovative therapeutic approaches that might limit the use of invasive surgical procedures (e.g., spine fusion and arthrop...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2013
ISSN: 0021-9738
DOI: 10.1172/jci69277